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Multiple myeloma preparative regimens for high-dose therapy and autologous transplantation: what’s new? Journal Article


Authors: Aljitawi, Omar S; McGuirk, Joseph P
Article Title: Multiple myeloma preparative regimens for high-dose therapy and autologous transplantation: what’s new?
Abstract: High-dose chemotherapy and autologous stem cell transplantation remains a standard procedure in relatively young and selected older patients with multiple myeloma. High-dose melphalan has remained the chemotherapeutic agent of choice based on earlier prospective randomized trials. Despite investigations involving different combinations of chemotherapeutics, radiation and novel agents with and without melphalan, none of these alternative preparative regimens have demonstrated superiority to high-dose melphalan used as a single agent in multiple published studies. In this article, we review the published literature regarding preparative regimens used in patients with multiple myeloma undergoing autologous stem cell transplantation.
Journal Title: Journal of Comparative Effectiveness Research
Volume: 1
Issue: 1
ISSN: 2042-6305, 2042-6313
Publisher: Unknown  
Date Published: 2013-02-05
Start Page: 57
End Page: 70
DOI/URL: