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A retrospective study of amitriptyline in youth with autism spectrum disorders Journal Article


Authors: Bhatti, Irfan; Thome, Andrew; Smith, Patricia Oxler; Cook Wiens Galen; Yeh, Hung-Wen; Gaffney, Gary R; Hellings, Jessica A
Article Title: A retrospective study of amitriptyline in youth with autism spectrum disorders
Alternate Title: Journal of autism and developmental disorders
Journal Title: Journal of autism and developmental disorders
Volume: 43
Issue: 5
ISSN: 1573-3432
Publisher: Unknown  
Date Published: 2013
Start Page: 1017
End Page: 1027
DOI/URL:
Notes: We performed a retrospective chart review of 50 youths with Autism Spectrum Disorder (ASD), prescribed amitriptyline (AMI) for hyperactivity and impulsivity. Data was systematically extracted from 50 outpatient clinic charts, including AMI treatment duration, dose, trough levels and adverse events. Mean age was 9.4 years (4.6-17.9); 40 were males and 10 females. 30 % had failed atomoxetine and 40 % had failed ≥3 ADHD medications. Mean dose was 1.3 ± 0.6 mg/kg/day, mean trough level 114.1 ± 50.5 ng/ml, mean duration 3.4 years. Clinical Global Impressions Scale-Improvement (CGI-I) was ≤2 in 60 % of patients at the final visit, and in 82 % of patients for at least 50 % of follow-ups. Cautious use of low dose AMI shows promise for treatment-resistant youth with ASD accompanied by hyperactivity, impulsivity, aggression and self injury.
KUMC Authors
  1. Hung-Wen (Henry) Yeh
    39 Yeh