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Short-Term Soy Isoflavone Intervention in Patients with Localized Prostate Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial Journal Article


Authors: Hamilton Reeves Jill M; Banerjee, Snigdha; Banerjee, Sushanta K.; Holzbeierlein, Jeffrey M; Thrasher, J Brantley; Kambhampati, Suman; Keighley John; van Veldhuizen, Peter
Article Title: Short-Term Soy Isoflavone Intervention in Patients with Localized Prostate Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
Alternate Title: PLoS ONE
Abstract: Purpose: We describe the effects of soy isoflavone consumption on prostate specific antigen (PSA), hormone levels, total cholesterol, and apoptosis in men with localized prostate cancer.Methodology/Principal Findings: We conducted a double-blinded, randomized, placebo-controlled trial to examine the effect of soy isoflavone capsules (80 mg/d of total isoflavones, 51 mg/d aglucon units) on serum and tissue biomarkers in patients with localized prostate cancer. Eighty-six men were randomized to treatment with isoflavones (nā€Š=ā€Š42) or placebo (nā€Š=ā€Š44) for up to six weeks prior to scheduled prostatectomy. We performed microarray analysis using a targeted cell cycle regulation and apoptosis gene chip (GEArrayTM). Changes in serum total testosterone, free testosterone, total estrogen, estradiol, PSA, and total cholesterol were analyzed at baseline, mid-point, and at the time of radical prostatectomy. In this preliminary analysis, 12 genes involved in cell cycle control and 9 genes involved in apoptosis were down-regulated in the treatment tumor tissues versus the placebo control. Changes in serum total testosterone, free testosterone, total estrogen, estradiol, PSA, and total cholesterol in the isoflavone-treated group compared to men receiving placebo were not statistically significant. Conclusions/Significance: These data suggest that short-term intake of soy isoflavones did not affect serum hormone levels, total cholesterol, or PSA.Trial RegistrationClinicalTrials.gov NCT00255125
Journal Title: PloS one
Volume: 8
Issue: 7
ISSN: 1932-6203
Publisher: Public Library of Science  
Date Published: 2013
DOI/URL: