Research Focus

My major interest is genetic regulatory mechanisms with emphasis on the delineation of the function of locus control regions (LCRs). Questions that I am pursuing include the structure/function relationships of the individual HSs composing the LCR, the structural features that are required for formation of the LCR holocomplex,the mechanism of interaction between the LCR and individual globin genes, and the mechanism whereby the LCR activates chromosomal domains. I also study other genetic regulatory mechanisms and disease pathogenesis using transgenic mouse models of sickle cell disease, Alzheimer's disease, Kennedy's disease, polycystic kidney disease and Alport's syndrome.