Safety assessment of 1,2-glycols as used in cosmetics Journal Article

Authors: Johnson Wilbur Jr; Bergfeld, Wilma F; Belsito, Donald V; Hill, Ronald A; Klaassen, Curtis D.; Liebler Daniel; Marks, James G Jr; Shank, Ronald C; Slaga, Thomas J; Snyder, Paul W; Andersen, F Alan
Article Title: Safety assessment of 1,2-glycols as used in cosmetics
Abstract: Caprylyl glycol and related 1,2-glycols are used mostly as skin and hair conditioning agents and viscosity agents in cosmetic products, and caprylyl glycol and pentylene glycol also function as cosmetic preservatives. The Cosmetic Ingredient Review (CIR) Expert Panel noted that, while these ingredients are dermally absorbed, modeling data predicted decreased skin penetration of longer chain 1,2-glycols. Because the negative oral toxicity data on shorter chain 1,2-glycols and genotoxicity data support the safety of the 1,2-glycols reviewed in this safety assessment, the Panel concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.
Journal Title: International journal of toxicology
Volume: 31
Issue: 5 Suppl
ISSN: 1092-874X
Publisher: Sage Publications  
Publication Place: United States
Date Published: 2012-09
Start Page: 147S
End Page: 68S
Language: eng
Identifier: 23064773
Notes: In-Process